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Product Name PGGT1B Chinese Name 香叶烯基转移酶1β抗体 Alias PGGT1B; GGTase-I beta; GGTase-1 beta; BGGI; Geranylgeranyl transferase type I subunit beta; Geranylgeranyl transferase type-1 subunit beta; GGTase-I-beta; GGTI; PGGT1B; PGTB1_HUMAN; Type I protein geranyl-geranyltransferase subunit beta; PGGT1β; GGTase-1 β; GGTase-I β. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 42kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PGGT1 beta: 301-377/377 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.
Subunit:
Heterodimer of an alpha and a beta subunit.
Similarity:
Belongs to the protein prenyltransferase subunit beta family.
Contains 4 PFTB repeats.
SWISS:
P53609
Gene ID:
5229
Database links:Entrez Gene: 5229 Human
Entrez Gene: 225467 Mouse
Omim: 602031 Human
SwissProt: P53609 Human
SwissProt: Q8BUY9 Mouse
Unigene: 254006 Human
Unigene: 262096 Mouse
Unigene: 393044 Mouse
Unigene: 10031 Rat
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