Product Name	PSMD7
Chinese Name	蛋白酶调解因子7抗体
Alias	26S proteasome non ATPase regulatory subunit 7; 26S proteasome non-ATPase regulatory subunit 7; 26S proteasome regulatory subunit rpn8; 26S proteasome regulatory subunit S12; Moloney leukemia virus 34 proviral integration; MOV 34; MOV 34L; MOV34; Mov34 homolog; Mov34 protein homolog; MOV34L; P40 antibody Proteasome (prosome macropain) 26S subunit non ATPase 7; Proteasome 26S non ATPase subunit 7; Proteasome 26S S12; Proteasome subunit p40; PSD7_HUMAN; PSMD 7; PSMD-7; PSMD7; S12 antibody.
Research Area	Cell biology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The nucleus cytoplasmic Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PSMD7: 31-130/324
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Subunit: Homodimer. Interacts with TRIM5. Similarity: Belongs to the peptidase M67A family. Contains 1 MPN (JAB/Mov34) domain. SWISS: P51665 Gene ID: 5713 Database links: Entrez Gene: 5713 Human Entrez Gene: 17463 Mouse Entrez Gene: 307821 Rat Omim: 157970 Human SwissProt: Q3ZBD0 Cow SwissProt: P51665 Human SwissProt: P26516 Mouse Unigene: 440604 Human Unigene: 18347 Mouse Unigene: 20659 Rat

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