Product Name	RNF149
Chinese Name	Ring finger protein149抗体
Alias	DNA polymerase-transactivated protein 2; E3 ubiquitin-protein ligase RNF149; RING finger protein 149; RN149_HUMAN; Rnf149.
literatures	Specific References  (1)     |     SL9228R has been referenced in 1 publications. [IF=6.409] Xiuxiu Jin. et al. Identification of age-associated proteins and functional alterations in human retinal pigment epithelium. GENOM PROTEOM BIOINF. 2022 Jun;:  WB ;  Human.   PubMed:35752290
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RNF149: 31-130/400
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF149 (RING finger protein 149), also known as DNAPTP2 (DNA polymerase-transactivated protein 2) or E3 ubiquitin-protein ligase RNF149, is a 400 amino acid single-pass membrane protein that contains one PA (protease associated) domain and a single RING-type zinc finger. The gene encoding RNF149 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. Subcellular Location: Membrane. Similarity: Contains 1 PA (protease associated) domain. Contains 1 RING-type zinc finger. SWISS: Q8NC42 Gene ID: 284996 Database links: Entrez Gene: 284996 Human Entrez Gene: 67702 Mouse Entrez Gene: 363222 Rat SwissProt: Q8NC42 Human SwissProt: Q3U2C5 Mouse Unigene: 142074 Human

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