Product Name	C1orf187/Draxin
Chinese Name	1号染色体开放阅读框187抗体
Alias	AGPA3119; C1orf187; Chromosome 1 open reading frame 187; Dorsal repulsive axon guidance protein; DRAXI_HUMAN; Draxin; Neucrin; UNQ3119.
literatures	Specific References  (1)     |     SL9220R has been referenced in 1 publications. [IF=2.866] Jia, Yulong. et al. DRAXIN as a Novel Diagnostic Marker to Predict the Poor Prognosis of Glioma Patients. J MOL NEUROSCI. 2022 Aug;:1-14  IHC ;  Human.   PubMed:36040678
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human C1orf187: 261-349/349
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Function: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (By similarity). Subunit: Interacts with LRP6 (By similarity). Subcellular Location: Secreted. Similarity: Belongs to the draxin family. SWISS: Q8NBI3 Gene ID: 374946 Database links: Entrez Gene: 374946 Human Entrez Gene: 70433 Mouse Entrez Gene: 691317 Rat Omim: 612682 Human SwissProt: Q8NBI3 Human SwissProt: Q6PAL1 Mouse Unigene: 632364 Human Unigene: 733197 Human Unigene: 275288 Mouse

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