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Rabbit Anti-Cystatin S antibody
Rabbit Anti-Cystatin S antibody
Cst4; Cystatin 4; Cystatin S precursor; Cystatin SA III; Cystatin-4; Cystatin-S; Cystatin-SA-III; CYTS_HUMAN; MGC71923; Salivary acidic protein 1.
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Details

Product Name Cystatin S
Chinese Name 胱抑素S/半胱氨酸蛋白酶抑制剂S抗体
Alias Cst4; Cystatin 4; Cystatin S precursor; Cystatin SA III; Cystatin-4; Cystatin-S; Cystatin-SA-III; CYTS_HUMAN; MGC71923; Salivary acidic protein 1.  
Research Area Cell biology  immunology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 16kDa
Cellular localization Secretory protein 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human Cystatin S: 51-141/141 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function. [provided by RefSeq, Jul2008].

Function:
This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.

Post-translational modifications:
Phosphorylated at both its N- and C-terminal regions.

Similarity:
Belongs to the cystatin family.

SWISS:
P01036

Gene ID:
1472

Database links:

Entrez Gene: 1472 Human

Omim: 123857 Human

SwissProt: P01036 Human

Unigene: 654549 Human



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