Product Name	POP1
Chinese Name	感染性蛋白唯一蛋白1抗体
Alias	PAAD domain only protein; POP1; PYDC1; Pyrin domain containing 1; Pyrin only protein 1; PYDC1_HUMAN.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	10kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ASC2/POP1: 11-70/89
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes. Function: Associates with apoptosis-associated specklike proteincontaining a CARD domain (ASC) and modulates its ability tocollaborate with pyrin and cryopyrin in NF-kappa-B andpro-caspase-1 activation. Suppresses kinase activity of NF-kappa-Binhibitor kinase (IKK) complex, expression of NF-kappa-B induciblegenes and inhibits NF-kappa-B activation by cytokines and LPS. Subunit: Interacts with PYCARD/ASC. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in monocytes,macrophages and granulocytes. Post-translational modifications: Phosphorylated. Similarity: Contains 1 DAPIN domain. SWISS: Q8WXC3 Gene ID: 260434 Database links: Entrez Gene: 260434 Human SwissProt: Q8WXC3 Human Unigene: 58314 Human

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