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Product Name FBXW12 Chinese Name FBXW12蛋白抗体 Alias F box and WD 40 domain containing protein 12; F box and WD 40 domain protein 12; F box and WD repeat domain containing 12; F box and WD40 repeat containing protein; F box only protein 35; F box/WD repeat containing protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; F-box/WD repeat-containing protein 12; Fbw12; FBW12_HUMAN; FBX12; FBXO12; FBXO35; FBXW 12; FBXW12. Research Area Cell biology immunology Signal transduction Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 53kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FBXW12/FBXO35: 101-200/464 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues.
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).
Subunit:
Directly interacts with SKP1 and CUL1
Tissue Specificity:
Ubiquitously expressed
Similarity:
Contains 1 F-box domain.
Contains 5 WD repeats.
SWISS:
Q6X9E4
Gene ID:
285231
Database links:Entrez Gene: 285231 Human
Omim: 609075 Human
SwissProt: Q6X9E4 Human
Unigene: 288793 Human
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