Product Name	AKIRIN2
Chinese Name	AKIRIN2蛋白抗体
Alias	AKIR2_HUMAN; AKIRIN 2; Akirin-2; Akirin2; C6orf166; dJ486L4.2; FBI1; FLJ10342; Fourteen three three beta interactant 1.
Research Area	Cell biology  immunology  Chromatin and nuclear signals  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human AKIRIN2: 51-150/203
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1. Function: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Subunit: Interacts with YWHAB (By similarity). Subcellular Location: Nucleus Tissue Specificity: Widely expressed with the highest expression in peripheral blood leukocytes Similarity: Belongs to the akirin family. SWISS: Q53H80 Gene ID: 55122 Database links: Entrez Gene: 55122 Human Entrez Gene: 433693 Mouse Entrez Gene: 297968 Rat Omim: 615165 Human SwissProt: Q53H80 Human SwissProt: B1AXD8 Mouse SwissProt: Q25C79 Rat Unigene: 485915 Human Unigene: 389532 Mouse Unigene: 399624 Mouse Unigene: 3858 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN2) Polyclonal Antibody, Unconjugated (SL9082R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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