Product Name	HIG1/HIGD1A
Chinese Name	缺氧诱导基因1蛋白/HIGD1A抗体
Alias	Hig1; HIG1 domain family member 1A; HIG1 domain family, member 1A; HIG1 hypoxia inducible domain family, member 1A; HIG1A_HUMAN; HIGD1A; HIMP1; Hypoxia-inducible gene 1 protein.
Research Area	Tumour  Cell biology  immunology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Horse, )
Applications	ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	10kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HIG1/HIGD1A: 25-70/93
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	HIGD1A (HIG1 domain family member 1A), also known as HIG1 (hypoxia-inducible gene 1 protein) or HSPC010, is a 93 amino acid multi-pass membrane protein that contains one HIG1 domain. Existing as two alternatively spliced isoforms, the gene encoding HIGD1A maps to human chromosome 3, which contains approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. Function: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. Subunit: Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respratory chain supercomplexes. Subcellular Location: Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane (Probable). Similarity: Contains 1 HIG1 domain. SWISS: Q9Y241 Gene ID: 25994 Database links: Entrez Gene: 25994 Human Entrez Gene: 56295 Mouse Entrez Gene: 140937 Rat SwissProt: Q9Y241 Human SwissProt: Q9JLR9 Mouse SwissProt: Q8VH49 Rat Unigene: 593134 Human Unigene: 728813 Human Unigene: 7917 Human Unigene: 347915 Mouse Unigene: 2084 Rat

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