Product Name	TENM3
Chinese Name	固生蛋白3抗体
Alias	TEN3_HUMAN; Teneurin-3; Ten-3; Protein Odd Oz/ten-m homolog 3; Tenascin-M3; Ten-m3; Teneurin transmembrane protein 3; KIAA1455; ODZ3; TNM3;
literatures	Specific References  (1)     |     SL9061R has been referenced in 1 publications. [IF=1.785] Peng Lin. et al. Curcumin relieves mice gastric emptying dysfunction induced by L‑arginine and atropine through interstitial cells of Cajal. Exp Ther Med. 2021 Jun;21(6):1-6  WB ;  Mouse.   PubMed:33850520
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	301kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TENM3: 1721-1850/2699 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the teneurin transmembrane protein family. The encoded protein may be involved in the regulation of neuronal development including development of the visual pathway. Mutations in this gene have been associated with microphthalmia and developmental dysplasia of the hip. [provided by RefSeq, Jan 2023] Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity). Subunit: Homodimer; disulfide-linked (Probable). Subcellular Location: Membrane; Single-pass type II membrane protein.Cell projection, axon (By similarity). Tissue Specificity: Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus. DISEASE: Note=Defects in TENM3 are a cause of microphthalmia, isolated, with coloboma (MCOPCB). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). [SIMILARITY] Belongs to the tenascin family. Teneurin subfamily. Similarity: Contains 8 EGF-like domains. Contains 5 NHL repeats. Contains 1 teneurin N-terminal domain. Contains 23 YD repeats. SWISS: Q9P273 Gene ID: 55714 Database links: Entrez Gene: 55714 Human Entrez Gene: 23965 Mouse Omim: 610083 Human SwissProt: Q9P273 Human SwissProt: Q9WTS6 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human esophageal cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ODZ3) Polyclonal Antibody, Unconjugated (SL9061R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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