Product Name	RCBTB1
Chinese Name	鸟嘌呤核苷酸交换因子抗体
Alias	Chronic lymphocytic leukemia deletion region gene 7 protein; CLL deletion region gene 7 protein; CLLD7; CLLL7 protein; Guanine nucleotide exchange factor; broad-complex, tramtrack and bric a brac; Hypothetical protein FLJ39335; RCBT1_HUMAN; Rcbtb1; RCC1 and BTB domain-containing protein 1; Regulator of chromosome condensation and BTB domain-containing protein 1.
Research Area	Tumour  Cell biology  immunology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	58kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RCBTB1/CLLD7: 301-400/531
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The BTB domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. RCBTB1 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1), also known as GLP, CLLD7, CLLL7 or E4.5, is a 531 amino acid protein that localizes to the nucleus and contains two BTB (POZ) domains and six RCC1 repeats. Expressed ubiquitously, RCBTB1 is thought to be involved in cell cycle regulation, specifically via chromatin remodeling. The gene encoding RCBTB1 maps to a region on human chromosome 13 that is frequently deleted in B-cell chronic lymphocytic leukemia, suggesting a possible role for RCBTB1 in tumor suppression. Function: May be involved in cell cycle regulation by chromatin remodeling. Subcellular Location: Nucleus (Potential). Tissue Specificity: Ubiquitously expressed Similarity: Contains 2 BTB (POZ) domains. Contains 6 RCC1 repeats. SWISS: Q8NDN9 Gene ID: 55213 Database links: Entrez Gene: 55213 Human Entrez Gene: 71330 Mouse Entrez Gene: 361050 Rat Omim: 607867 Human SwissProt: Q8NDN9 Human SwissProt: Q6NXM2 Mouse Unigene: 508021 Human Unigene: 234195 Mouse Unigene: 229110 Rat

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