Product Name	SCCD
Chinese Name	抑癌蛋白UBIAD1抗体
Alias	UBIAD1; RP4-796F18.1; SCCD; TERE 1; tere1; Transitional epithelia response protein; Transitional epithelial response protein 1; UbiA prenyltransferase domain containing 1; UbiA prenyltransferase domain containing protein 1; UbiA prenyltransferase domain-containing protein 1; UBIA1_HUMAN; UBIAD 1; Ubiad1.
Research Area	Tumour  Cell biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SCCD: 2-100/338
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008] Function: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. Subcellular Location: Endoplasmic reticulum membrane. Cytoplasm. Nucleus. Mitochondrion. Tissue Specificity: Ubiquitously expressed. DISEASE: Defects in UBIAD1 are the cause of crystalline corneal dystrophy of Schnyder (SCCD) [MIM:121800]. SCCD is a rare autosomal dominant disease characterized by progressive corneal opacification resulting from abnormal deposition of cholesterol and phospholipids. Similarity: Belongs to the ubiA prenyltransferase family. SWISS: Q9Y5Z9 Gene ID: 29914 Database links: Entrez Gene: 29914 Human Entrez Gene: 71707 Mouse Entrez Gene: 313706 Rat Omim: 611632 Human SwissProt: Q9Y5Z9 Human SwissProt: Q9DC60 Mouse SwissProt: D3ZG27 Rat Unigene: 522933 Human Unigene: 292503 Mouse Unigene: 203344 Rat

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