Product Name	PRSS1
Chinese Name	丝氨酸蛋白酶1抗体
Alias	Alpha trypsin chain 1; Alpha-trypsin chain 1; Alpha-trypsin chain 2; Beta-trypsin; Beta trypsin; Cationic trypsinogen; Serine protease 1; Serine protease-1; TRP1; TRY1; TRY1_HUMAN; TRYP1; Trypsin I; Trypsin-I; Trypsin 1; Trypsin-1.
Research Area	Cell biology  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Dog, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PRSS1: 51-150/247
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008] Function: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. Subcellular Location: Secreted > extracellular space. Post-translational modifications: Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122. DISEASE: Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. SWISS: P07477 Gene ID: 5644 Database links: Entrez Gene: 5644 Human Entrez Gene: 114228 Mouse Entrez Gene: 24691 Rat Omim: 276000 Human SwissProt: P00760 Cow SwissProt: P07477 Human SwissProt: P00762 Rat Unigene: 449281 Human Unigene: 449428 Mouse Unigene: 34435 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PRSS1) Polyclonal Antibody, Unconjugated (SL8744R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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