Product Name	RAB13
Chinese Name	G蛋白家族RAB13蛋白抗体
Alias	RAB13_HUMAN; Cell growth-inhibiting gene 4 protein; GIG4; Growth inhibiting gene 4 protein; RAB13 member RAS oncogene family; RAS associated protein RAB13; Ras related protein Rab13; Ras-related protein Rab-13.
Research Area	Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RAB13: 51-150/203
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013] Subunit: Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with CCDC64B/BICDR2. Interacts with LEPROT and LEPROTL1. Subcellular Location: Cell junction. tight junction. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Tissue Specificity: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells. Similarity: Belongs to the small GTPase superfamily. Rab family. SWISS: P51153 Gene ID: 5872 Database links: Entrez Gene: 514541 Cow Entrez Gene: 5872 Human Entrez Gene: 68328 Mouse Entrez Gene: 81756 Rat Entrez Gene: 373105 Zebrafish Omim: 602672 Human SwissProt: Q58DS5 Cow SwissProt: P51153 Human SwissProt: Q5U0A6 Human SwissProt: Q9DD03 Mouse SwissProt: P35286 Rat SwissProt: Q7T3A4 Zebrafish Unigene: 151536 Human Unigene: 29355 Mouse Unigene: 9819 Rat

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