Product Name	SLC30A3
Chinese Name	溶质载体锌转运3抗体
Alias	SLC30A3; Solute carrier family 30 (zinc transporter), member 3; Solute carrier family 30 member 3; Zinc transporter 3; Zinc transporter ZnT 3; ZnT-3; ZNT3; ZNT3_HUMAN; OTTHUMP00000201041.
literatures	Specific References  (1)     |     SL8717R has been referenced in 1 publications. [IF=7.419] Jinfeng Shang. et al. Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements. BIOMED PHARMACOTHER. 2023 May;161:114534  IHC ;  Rat.   PubMed:36933376
Research Area	Neurobiology  transcriptional regulatory factor  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC30A3/ZNT3: 21-120/388
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions, including acting as a cofactor for numerous enzymes and transcription factors and as a neuroregulator. The zinc transporter (ZnT) family regulates the supply of zinc within cells, and its members are characterized by containing six membrane-spanning domains, a large histidine-rich intracellular loop, and a C-terminal tail. ZnT-3 mediates the uptake of zinc into vesicles in brain and testis. Function: Involved in accumulation of zinc in synaptic vesicles. Subunit: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. Subcellular Location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (Probable). Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. SWISS: Q99726 Gene ID: 7781 Database links: Entrez Gene: 7781 Human Entrez Gene: 22784 Mouse Entrez Gene: 366568 Rat Omim: 602878 Human SwissProt: Q99726 Human SwissProt: P97441 Mouse SwissProt: Q6QIX3 Rat Unigene: 467981 Human Unigene: 1396 Mouse Unigene: 9297 Rat
Product Picture	Positive sample：Paraformaldehyde-fixed, paraffin embedded (mouse brain); Negative sample：Paraformaldehyde-fixed, paraffin embedded (rat intestine); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC30A3) Polyclonal Antibody, Unconjugated (SL8717R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-SLC30A3 Polyclonal Antibody, Unconjugated(SL8717R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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