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Product Name PTPLAD1 Chinese Name 蛋白酪氨酸磷酸酶样A结构域蛋白1抗体 Alias B IND1; Butyrate induced protein 1; Butyrate induced transcript 1; FLJ90376; hB ind1; HSPC121; Protein tyrosine phosphatase like A domain containing 1; PTPLAD 1. Research Area Cell biology Signal transduction Kinases and Phosphatases Epigenetics G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 43kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PTPLAD1: 1-100/362 <Cytoplasmic> Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail PTPLAD1 is a component of Rac1-signaling pathways leading to the modulation of gene expression. It potentiates different effects of the small GTPase Rac1, such as c-Jun N-terminal kinase activation and transcriptional activity of nuclear factor kappaB (NF-kappaB).It plays a crucial role in HCV RNA replication and the propagation of JFH1 virus through interaction with viral and host proteins.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the very long-chain fatty acids dehydratase HACD family.
Contains 1 CS domain.
SWISS:
Q9P035
Gene ID:
51495
Database links:Entrez Gene: 51495 Human
Entrez Gene: 57874 Mouse
SwissProt: Q9P035 Human
SwissProt: Q8K2C9 Mouse
Unigene: 512973 Human
Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTPLAD1) Polyclonal Antibody, Unconjugated (SL8693R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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