Product Name	MEPE
Chinese Name	Extracellular matrixPhosphorylated anti
Alias	Matrix extracellular phosphoglycoprotein; MEPE; MEPE_HUMAN; OF45; Osteoblast/osteocyte factor 45.
literatures	Specific References  (1)     |     SL8689R has been referenced in 1 publications. [IF=3.423] Baris Ozgur Donmez. et al. Calcium‑dependent activation of PHEX, MEPE and DMP1 in osteocytes. MOL MED REP. 2022 Dec;26(6):1-11  WB ;  Mouse.   PubMed:36281920
Research Area	immunology  Developmental biology  Signal transduction  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	56kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MEPE: 201-300/525
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MEPE is a 525 amino acid extracellular matrix protein. Expressed in osteocytes and brain, MEPE is a regulator of bone metabolism that is thought to mediate mineralization and demineralization within the osteocyte microenvironment. MEPE contains an RGD cell-attachment motif and shares molecular similarities with several dentin-bone extracellular matrix RGD-containing phosphoglycoproteins, including OPN (osteopontin) and DSP (dentin sialophosphoprotein). Via its ability to control bone mineralization, MEPE is associated with various developmental events such as skeletogenesis, bone regeneration and odontogenesis. MEPE is secreted in hypophosphatemic osteomalacia tumors, suggesting a possible role in the pathophysiology of bone-related cancers. Function: Seems to play a role in mineralization. Subcellular Location: Secreted Tissue Specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors. Post-translational modifications: Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif. SWISS: Q9NQ76 Gene ID: 56955 Database links: Entrez Gene: 56955 Human Entrez Gene: 94111 Mouse Entrez Gene: 79110 Rat Omim: 605912 Human SwissProt: Q9NQ76 Human Unigene: 676357 Human Unigene: 196672 Mouse Unigene: 160717 Rat
Product Picture	Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Mouse Spleen tissue lysates Lane 4: Mouse Cerebellum tissue lysates Lane 5: Human HepG2 cell lysates Lane 6: Human MCF-7 cell lysates Primary: Anti-MEPE (SL8689R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kDa Observed band size: 47,62 kDa

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