Product Name	IFI202
Chinese Name	γInterferon诱导蛋白202抗体
Alias	IFI-202; IFI 202; fi202a; Ifi202b; Interferon-activable protein 202; Interferon-inducible protein p202; Lupus susceptibility protein p202; IFI2_MOUSE.
Research Area	Cardiovascular  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IFI-202: 121-220/445
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IFI-202 is a primarily nuclear phosphoprotein which inhibits cell growth, in part by modulating transcriptional activity of NFkB, E2F, AP-1 and p53. Two related human proteins, MNDA (myeloid cell nuclear differentiation antigen) and IFI-16, have also been described. Expression of MNDA has been observed specifically in cells of the granulocyte-macrophage lineage. IFI-16 is constitutively expressed in various T and B cell lines and can be induced by IFN-g in HL60 cells. At least four of the Gene 200 cluster of IFN-inducible proteins, IFI-202, IFI-204, MNDA and IFI-16, are localized in the nucleus. Function: Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2. Subunit: Binds to several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Also binds p53, the hypophosphorylated, growth-inhibitory form of the retinoblastoma protein and the p53-binding protein 1 (53BP1). Subcellular Location: Cytoplasm. Nucleus. Note=Accumulates first in the cytoplasm, and is translocated to the nucleus after a delay, where it is primarily chromatin-associated. Post-translational modifications: Phosphorylated. Similarity: Belongs to the HIN-200 family. Contains 2 HIN-200 domains. SWISS: Q9R002 Gene ID: 100044068
Product Picture	Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti-IFI-202 (SL8676R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD Sample: Lymph (Mouse) Lysate at 40 ug Primary: Anti-IFI-202 (SL8676R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IFI-202 Polyclonal Antibody, Unconjugated(SL8676R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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