Product Name	GPR7
Chinese Name	G protein-coupled receptor7抗体
Alias	GPCR GPR7; G protein coupled receptor 7; g protein coupled receptor gpr7; GPR7; MGC129755; Neuropeptides B and W receptor 1; Neuropeptides B/W receptor 1; Neuropeptides B/W receptor type 1; NPB and NPW receptor 1; NPBWR1; opioid somatostatin like receptor 7.
literatures	Specific References  (5)     |     SL8618R has been referenced in 5 publications. [IF=6.208] Shashank Pandey. et al. Regulation of Prepro-NeuropeptideW/B and Its Receptor in the Heart of ZDF Rats: An Animal Model of Type II DM. INT J MOL SCI. 2022 Jan;23(23):15219  WB ;  Rat.   PubMed:36499546 [IF=6.208] Tatiana Wojciechowicz. et al. The Effects of Neuropeptide B on Proliferation and Differentiation of Porcine White Preadipocytes into Mature Adipocytes. INT J MOL SCI. 2023 Jan;24(7):6096  WB ;  Pig.   PubMed:37047072 [IF=4.556] Shashank Pandey. et al. Identification of NPB, NPW and Their Receptor in the Rat Heart. Int J Mol Sci. 2020 Jan;21(21):7827  WB,IF ;  Rat.   PubMed:33105700 [IF=4.369] T. Wojciechowicz. et al. Neuropeptide B promotes differentiation of rodent white preadipocytes into mature adipocytes. MOL CELL ENDOCRINOL. 2023 Jan;:111850  WB ;  Rat.   PubMed:36623583 [IF=2.231] Tatiana Wojciechowicz. et al. Neuropeptide B promotes proliferation and differentiation of rat brown primary preadipocytes. 2021 Feb 24  WB ;  Rat.   PubMed:33629519
Research Area	Cell biology  Neurobiology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GPR7: 1-100/540 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively. Function: GPR7 interacts specifically with a number of opioid ligands. It is a receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals, and has a higher affinity for neuropeptide B. It has been reported in brain, mainly cerebellum and frontal cortex, and in the pituitary (O'Dowd et al., 1995). The mouse ortholog of GPR7 was shown by in situ hybridization to be expressed in discrete nuclei of brain, namely suprachiasmatic, arcuate, and ventromedial nuclei of hypothalamus. Subcellular Location: Cell membrane; Multipass membrane protein. SWISS: O95800 Gene ID: 10936 Database links: Entrez Gene: 428544 Chicken Entrez Gene: 539470 Cow Entrez Gene: 101130191 Gorilla Entrez Gene: 100066961 Horse Entrez Gene: 10936 Human Entrez Gene: 237716 Mouse Entrez Gene: 100517153 Pig Entrez Gene: 100347723 Rabbit Entrez Gene: 498434 Rat Omim: 606704 Human SwissProt: O95800 Human SwissProt: Q6X632 Mouse Unigene: 40763 Human Unigene: 338361 Mouse Unigene: 484157 Mouse
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-GPR7 (SL8618R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD

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