Product Name	Ribonuclease 3/ECP
Chinese Name	嗜酸性粒细胞阳离子蛋白抗体
Alias	eosinophil cationic protein; EAR; Ear11; Ear4; EAR5; ECP; LOC192264; MGC143624; mR3; mR5; R1; R14; R15; R17; R5; R7; Ribonuclease 3; Rnase17; Rnase2; RNASE3; RNS3; ECP_HUMAN.
literatures	Specific References  (4)     |     SL8615R has been referenced in 4 publications. [IF=12.05] Fujisawa, Daisuke, et al. "Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria." Journal of Allergy and Clinical Immunology (2014).  IHC-F ;  Human.   PubMed:24954276 [IF=4.082] Yoshimasa Imoto. et al. Enhanced 15-Lipoxygenase 1 Production is Related to Periostin Expression and Eosinophil Recruitment in Eosinophilic Chronic Rhinosinusitis. Biomolecules. 2020 Nov;10(11):1568  IF ;  Human.   PubMed:33218117 [IF=2.36] Inada, Noriko, et al. "Histamine H 1 and H 4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases." Allergology International (2017).  IF(ICC) ;  Human.   PubMed:28391980 [IF=2.36] Tokunaga, Takahiro, et al. "The significant expression of TRPV3 in nasal polyps of eosinophilic chronic rhinosinusitis." Allergology International (2017).  IHC-P ;  Human.   PubMed:28462829
Research Area	Cell biology  immunology  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 ICC=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Ribonuclease 3: 45-160/160
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ECP is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities. It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis, and tremor that may lead to death. ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity. Subcellular Location: Cytoplasmic granule. Matrix of eosinophil's large specific granule. Similarity: Belongs to the pancreatic ribonuclease family. SWISS: P12724 Gene ID: 6037 Database links: Entrez Gene: 6037 Human Entrez Gene: 53876 Mouse Entrez Gene: 100361866 Rat Entrez Gene: 192264 Rat Omim: 131398 Human SwissProt: P12724 Human SwissProt: O35290 Mouse SwissProt: P70709 Rat Unigene: 73839 Human Unigene: 327386 Mouse Unigene: 10626 Rat
Product Picture	Western blot analysis of lysate from human spleen tissue lysate, using RNASE3 Antibody (C-term)(Cat. #SL8615R). AP13557b was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug. RNASE3 Antibody (C-term) (Cat. #SL8615R) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RNASE3 antibody detected the RNASE3 protein (arrow). Confocal immunofluorescent analysis of RNASE3 Antibody (C-term) (Cat#SL8615R) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

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