Product Name	GPR120
Chinese Name	G protein-coupled receptor120抗体
Alias	G protein coupled receptor 120; GPCR GPR120; G protein coupled receptor 129; G protein coupled receptor GT01; G protein coupled receptor PGR 4; G protein coupled receptor PGR4; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; GPR 120; GPR 129; GPR120; GPR129; GT01; HGNC:19345; MGC119984; O3FA1_HUMAN; O3FAR1; Omega-3 fatty acid receptor 1; PGR 4; PGR4; GPCR120.
literatures	Specific References  (3)     |     SL8596R has been referenced in 3 publications. [IF=5.396] Xiaohua Yang. et al. Cytochrome P450 epoxygenase-derived EPA and DHA oxylipins 17, 18-epoxyeicosatetraenoic acid and 19, 20-epoxydocosapentaenoic acid promote BAT thermogenesis and WAT browning through GPR120-AMPKα signaling pathway. Food Funct. 2021 Dec;:  WB ;  Mouse.   PubMed:35019933 [IF=4.872] Chunling Huang. et al. Exposure to ethephon compromises endometrial decidualization in mice during early pregnancy via GPR120. Ecotox Environ Safe. 2021 Sep;220:112361  WB ;  Mouse.   PubMed:34052757 [IF=2.47] Meng, Yingying, et al. "Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice." Biochemical and Biophysical Research Communications (2017).  WB ;  Mouse.   PubMed:28712865
Research Area	Tumour  Cell biology  Signal transduction  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human G protein coupled receptor 120: 21-120/377 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes. Function: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids. Subunit: Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation. Subcellular Location: Cell membrane. Colocalized with ARRB2 following DHA treatment. Tissue Specificity: Abundant expression in the intestinal tract. Post-translational modifications: Phosphorylated. FFA stimulation facilitates phosphorylation. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q5NUL3 Gene ID: 338557 Database links: Entrez Gene: 338557 Human Omim: 609044 Human SwissProt: Q5NUL3 Human Unigene: 661022 Human

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