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Product Name Cathepsin S Chinese Name 组织蛋白酶S抗体 Alias CathepsinS; Cathepsin S;CATS_HUMAN;CTSS. literatures Specific References (2) | SL8558R has been referenced in 2 publications.[IF=6.126] Diana Oelschlaegel. et al. Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages. Cancers. 2020 Sep;12(9):2579 WB ; Mouse.[IF=5.215] Tianrui Zhang. et al. Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization. PHARMACEUTICALS-BASE. 2023 Feb;16(2):243 WB ; Rat.Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 24kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Cathepsin S: 121-250/331 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O (1-6). The aspartyl protease class is composed of cathepsins D and E (7,8). Cathepsin G is in the serine protease class (9). Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsin S has been shown to be an elastinolytic cysteine proteinase present in aveloar macrophages.
Function:
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
Subunit:
Monomer.
Subcellular Location:
Lysosomal.
Similarity:
Belongs to the peptidase C1 family.
SWISS:
P25774
Gene ID:
1520
Database links:
Entrez Gene: 1520 Human
Omim: 116845 Human
SwissProt: P25774 Human
Unigene: 181301 Human
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