Product Name	MtTF1/TFAM
Chinese Name	Mitochondrion转录因子1抗体
Alias	Mitochondrial transcription factor 1; mitochondrial transcription factor A; MtTF1; mtTFA; TCF 6; TCF-6; TCF6; TCF6L1; TCF6L2; TCF6L3; TFAM; TFAM_HUMAN; Transcription factor 6 ; Transcription factor 6 like 2 (mitochondrial transcription factor); Transcription factor 6 like 2; Transcription factor 6-like 2; Transcription factor A, mitochondrial; Transcription factor A, mitochondrial precursor.
literatures	Specific References  (7)     |     SL8520R has been referenced in 7 publications. [IF=4.966] Guangning Kou. et al. Nobiletin activates thermogenesis of brown and white adipose tissue in high‐fat diet‐fed C57BL/6 mice by shaping the gut microbiota. Faseb J. 2021 Feb;35(2):e21267  WB ;  Mouse.   PubMed:33475201 [IF=3.974] Ning X et al.Ambient PM2. 5 causes lung injuries and coupled energy metabolic disorder. (2018) Ecotoxicol. Environ. Saf. 170  WB ;  Mouse.   PubMed:30579162 [IF=3.95] Yan, Wei, et al. "Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain." Environmental Research 138 (2015): 416-424.  WB ;  Rat.   PubMed:25791864 [IF=3.258] Liu H et al. Cybrid Model Supports Mitochondrial Genetic Effect on Pig Litter SizeFront Genet.2020 Dec 15;11:579382.  WB ;  pig.   PubMed:33384712 [IF=3.04] Yan et al. Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice. (2018) Endocr.Connect. 7:604-616  IF ;  Mouse.   PubMed:29678877 [IF=2.84] You, Yan, et al. "Protective Effects of PGC-1α via the Mitochondrial Pathway in Rat Brains after Intracerebral Hemorrhage." Brain Research(2016).  WB ;  Rat.   PubMed:27178364 [IF=2.566] Bryant JL et al. Glomerular mitochondrial changes in HIV associated renal injury.Exp Mol Pathol. 2018 Jun;104(3):175-189.  IHC&WB ;  Mouse.   PubMed:29608912
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Signal transduction  transcriptional regulatory factor  Mitochondrion  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Rabbit, Sheep, Goat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MtTF1: 155-246/246
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. target DNA. Interacts with TFB1M and TFB2M. Function: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. Target DNA. Interacts with TFB1M and TFB2M. Associates with mitochondrial DNA. Subcellular Location: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Similarity: Contains 2 HMG box DNA-binding domains. SWISS: Q00059 Gene ID: 7019 Database links: Entrez Gene: 7019 Human Omim: 600438 Human SwissProt: Q00059 Human Unigene: 594250 Human Unigene: 642966 Human
Product Picture	Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MtTF1 Polyclonal Antibody, Unconjugated(SL8520R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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