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Product Name FBXL15 Chinese Name FBXL15蛋白抗体 Alias F box and leucine rich repeat protein 15; F box only protein 37; F box/LRR repeat protein 15; Fbl15; FBXO37; FLJ16137; JET; OTTHUMP00000020367; OTTHUMP00000059115; OTTHUMP00000059124; OTTHUMP00000059125; Pleckstrin and Sec7 domain protein; PSD; MGC11279; FXL15_HUMAN. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 33kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FBXL15: 201-300/300 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail FBXL15 probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors. FBL15 (F-box and leucine-rich repeat protein 15), also known as FBXL15, FBXO37, PSD or JET, is a 296 amino acid protein that contains one F-box domain and functions as a component of the SCF complex, possibly playing a role in the ubiquitination and subsequent degradation of target proteins.
Function:
Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
Subunit:
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the FBXL15 family.
Contains 1 F-box domain.
Contains 5 LRR (leucine-rich) repeats.
SWISS:
Q9H469
Gene ID:
79176
Database links:Entrez Gene: 79176 Human
Entrez Gene: 68431 Mouse
Omim: 610287 Human
SwissProt: Q9H469 Human
SwissProt: Q91W61 Mouse
Unigene: 380081 Human
Unigene: 19973 Mouse
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