Product Name	FNDC1
Chinese Name	Ⅲ型纤维连接蛋白域蛋白1抗体
Alias	Activation-associated cDNA protein; AGS8; Expressed in synovial lining protein; fibronectin type III domain containing 2; Fibronectin type III domain-containing protein 1; FNDC1; FNDC1_HUMAN; FNDC2; MEL4B3.
literatures	Specific References  (1)     |     SL8460R has been referenced in 1 publications. [IF=4.848] Jiang T et al. FNDC1 Promotes the Invasiveness of Gastric Cancer via Wnt/β-Catenin Signaling Pathway and Correlates With Peritoneal Metastasis and PrognosisFront Oncol.2020 Dec 17;10:590492.  IHC ;  Human.   PubMed:33392086
Research Area	Cell biology  immunology  Epigenetics  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	202kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FNDC1: 21-120/1894
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G∫ and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events. Function: May be an activator of G protein signaling Subcellular Location: Secreted. Tissue Specificity: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis. Similarity: Contains 5 fibronectin type-III domains. SWISS: Q4ZHG4 Gene ID: 84624 Database links: UniProtKB/Swiss-Prot: Q4ZHG4.4

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