Product Name	PTRF
Chinese Name	RNA聚合酶1和转录释放因子抗体
Alias	Cavin; MGC118550; FKSG13; OTTMUSP00000002049; polymerase I and transcript release factor; RNA polymerase I and transcript release factor; RP23-279L23.6; TTF I interacting peptide 12; 2310075E07Rik; AW546441; PTRF_HUMAN.
Research Area	Cell biology  immunology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PTRF/RNA polymerase I and transcript release factor: 81-180/390
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pausing of elongation complexes is mediated by the transcription termination factor TTF-I bound to the 'Sal box' terminator downstream of the rDNA transcription unit. PTRF is a Pol I and transcript release factor for dissociation of paused ternary complexes. Function: Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. Subunit: Interacts with RNA polymerase I and TTF1. Binds the 3' end of pre-rRNA. Interacts with transcription factor ZNF148 (By similarity). Interacts with LIPE in the adipocyte cytoplasm. Subcellular Location: Cell membrane; caveola (surface). Cell membrane. Microsome. Cytoplasm; cytosol. Mitochondrion. Nucleus. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Post-translational modifications: Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity (By similarity). Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent. DISEASE: Defects in PTRF are the cause of congenital generalized lipodystrophy type 4 (CGL4) [MIM:613327]. It is a disorder characterized by the association of congenital generalized lipodystrophy with muscular dystrophy and cardiac anomalies. Congenital generalized lipodystrophy is characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Similarity: Belongs to the PTRF/SDPR family. SWISS: Q6NZI2 Gene ID: 284119 Database links: UniProtKB/Swiss-Prot: Q6NZI2.1
Product Picture	Tissue/cell: mouse stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PTRF Polyclonal Antibody, Unconjugated(SL8458R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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