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Product Name RAB40B Chinese Name RAS癌基因家族蛋白RAB40B抗体 Alias SEC4L; GTP binding protein homologous to Saccharomyces cerevisiae SEC4; RAB40B member RAS oncogene family; RAR; Rar protein; Ras related protein Rab 40B; RP23 293H17.2; SOCS box containing protein RAR; FLJ42385; RB40B_HUMAN. Research Area Tumour Cell biology immunology Signal transduction G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 31kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RAB40B: 121-220/278 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail RAB40B is similar to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. It may be a substrate recognition component of a SCF like ECS (Elongin Cullin SOCS box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Subcellular Location:
Cell membrane; Lipid anchor; Cytoplasmic side.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
Contains 1 SOCS box domain.
SWISS:
Q12829
Gene ID:
10966
Database links:Entrez Gene: 10966 Human
Entrez Gene: 217371 Mouse
SwissProt: Q12829 Human
SwissProt: Q8VHP8 Mouse
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