Product Name	PANK4
Chinese Name	泛酸激酶4抗体
Alias	DKFZp547M242; FLJ10782; hPanK 4; hPanK4; PANK 4; Pantothenate kinase 4; Pantothenic acid kinase; PANK4_HUMAN.
Research Area	Tumour  Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	86kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PANK4: 101-200/773
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PANK4 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the physiological regulation of the intracellular coenzyme A (CoA) concentration. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. Function: Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity). Subunit: Homodimer. Interacts with PKM (By similarity). Subcellular Location: Cytoplasm (Probable). Tissue Specificity: Ubiquitously expressed with higher expression in the muscle. Similarity: Belongs to the type II pantothenate kinase family. SWISS: Q9NVE7 Gene ID: 55229 Database links: Entrez Gene: 55229 Human Entrez Gene: 269614 Mouse Entrez Gene: 171053 Rat Omim: 606162 Human SwissProt: Q9NVE7 Human SwissProt: Q80YV4 Mouse SwissProt: Q923S8 Rat Unigene: 26156 Human Unigene: 30042 Mouse Unigene: 17321 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PANK4) Polyclonal Antibody, Unconjugated (SL8340R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PANK4) Polyclonal Antibody, Unconjugated (SL8340R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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