Product Name	phospho-Eg5 (Thr926)
Chinese Name	磷酸化驱动蛋白样蛋白1抗体
Alias	Eg5 (phospho T926); KIF11(phospho T926); TRIP5(phospho T926); p-Eg5(Thr926); p-KIF11(Thr926); p-TRIP5(Thr926); HKSP; KIF11; kinesin family member 11; Kinesin like protein 1; Kinesin like spindle protein HKSP; KNSL1; Thyroid receptor interacting protein 5; TRIP5; KIF11_HUMAN.
Product Type	Phosphorylated anti
Research Area	Cell biology  Signal transduction  Cytoskeleton  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Chicken, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	120kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human Eg5 around the phosphorylation site of Thr926: GT(p-T)PQ
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Eg5 is a motor protein that belongs to the kinesin-like family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays. Subunit: Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Post-translational modifications: Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR. A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function. Similarity: Belongs to the kinesin-like protein family. BimC subfamily. Contains 1 kinesin-motor domain. SWISS: P52732 Gene ID: 3832 Database links: Entrez Gene: 3832 Human Omim: 148760 Human SwissProt: P52732 Human Unigene: 8878 Human
Product Picture	Sample: HL-60(Human) Cell Lysate at 30 ug A431(Human) Cell Lysate at 30 ug U251(Human) Cell Lysate at 30 ug Primary: Anti-phospho-Eg5 (Thr926) (SL8179R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 120 kD Observed band size: 120 kD

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