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Product Name JMJD5 Chinese Name 组蛋白去甲基化酶JMJD5抗体 Alias JmjC domain-containing protein 5; JMJD5; JMJD5 protein; jumonji domain containing 5; Jumonji domain-containing protein 5; KDM8_HUMAN; Lysine-specific demethylase 8. Research Area Cell biology Chromatin and nuclear signals Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human JMJD5: 344-416/416 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009].
Function:
Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Weakly expressed in most cells. Highly expressed in breast cancer cells.
Similarity:
Contains 1 JmjC domain.
SWISS:
Q8N371
Gene ID:
79831
Database links:Entrez Gene: 79831 Human
Entrez Gene: 77035 Mouse
Omim: 611917 Human
SwissProt: Q8N371 Human
SwissProt: Q9CXT6 Mouse
Unigene: 145717 Human
Product Picture Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (JMJD5) Polyclonal Antibody, Unconjugated (SL8047R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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