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Rabbit Anti-COMMD4 antibody
Rabbit Anti-COMMD4 antibody
COMD4_HUMAN; COMM domain-containing protein 4; COMMD4.
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  • NO.:SL8037R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,Rat,(predicted: Mouse,Pig,Horse,)
    Applications:WB ELISA IHC-P IHC-F IF
    concentration:1mg/ml
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Details

Product Name COMMD4
Chinese Name COMM结构域蛋白4抗体
Alias COMD4_HUMAN; COMM domain-containing protein 4; COMMD4.  
literatures
Specific References  (1)     |     SL8037R has been referenced in 1 publications.
[IF=4.165] Amila Suraweera. et al. COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks. Commun Biol. 2021 Apr;4(1):1-11  IP ;  Human.  
Research Area Cell biology  immunology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human, Rat,  (predicted: Mouse, Pig, Horse, )
Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 22kDa
Cellular localization The nucleus cytoplasmic 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from Human COMMD4: 1-100/199 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail COMMD is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. Down-regulates activation of NF-kappa-B.

Function:
Down-regulates activation of NF-kappa-B.

Subunit:
Interacts (via COMM domain) with COMMD1 (via COMM domain).

Tissue Specificity:
Ubiquitous.

Similarity:
Contains 1 COMM domain.

SWISS:
Q9H0A8

Gene ID:
54939

Database links:

Entrez Gene: 54939 Human

SwissProt: Q9H0A8 Human

Unigene: 351327 Human



Product Picture
Tissue/cell: humun laryngocarcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-COMMD4 Polyclonal Antibody, Unconjugated(SL8037R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: humun laryngocarcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-COMMD4 Polyclonal Antibody, Unconjugated(SL8037R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-COMMD4 Polyclonal Antibody, Unconjugated(SL8037R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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