Product Name	ZP3
Chinese Name	卵母细胞透明带glycoprotein3抗体
Alias	ZP3_HUMAN; Zona pellucida sperm-binding protein 3; ZP3A; ZP3B; ZPC; Sperm receptor; ZP3A/ZP3B; Zona pellucida glycoprotein 3 (Zp-3); Zona pellucida protein C; Processed zona pellucida sperm-binding protein 3;
Research Area	Cell biology  immunology  Developmental biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZP3: 101-200/424 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Subcellular Location: Secreted > extracellular space > extracellular matrix and Cell membrane. Tissue Specificity: Oocytes. Post-translational modifications: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. N-glycosylated. O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy. Similarity: Belongs to the ZP domain family. ZPC subfamily. Contains 1 ZP domain. SWISS: P21754 Gene ID: 7784 Database links: Entrez Gene: 280964 Cow Entrez Gene: 511 Cow Entrez Gene: 7784 Human Omim: 182889 Human SwissProt: P48830 Cow SwissProt: P21754 Human Unigene: 130553 Human Unigene: 656137 Human

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