Product Name	CCDC6
Chinese Name	卷曲螺旋结构域蛋白6抗体
Alias	CCDC 6; Coiled coil domain containing 6; Coiled coil domain containing protein 6; D10S170; FLJ32286; H4; Papillary thyroid carcinoma encoded protein; Protein H4; PTC; TPC; TST 1; TST1; CCDC6_HUMAN.
Research Area	Tumour  Cell biology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CCDC6: 131-200/474
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton (Probable). Note=May be a cytoskeletal protein. Tissue Specificity: Ubiquitously expressed. DISEASE: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene. SWISS: Q16204 Gene ID: 8030 Database links: Entrez Gene: 8030 Human Entrez Gene: 76551 Mouse Omim: 601985 Human SwissProt: Q16204 Human SwissProt: D3YZP9 Mouse Unigene: 591360 Human Unigene: 281741 Mouse

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