Product Name	TPTE
Chinese Name	Tumour/睾丸抗原44抗体
Alias	Cancer/testis antigen 44; CT44; EC=3.1.3.48; HGNC:12023; PTEN2; Putative tyrosine protein phosphatase; Putative tyrosine-protein phosphatase TPTE; TPTE; TPTE_HUMAN; Transmembrane phosphatase with tensin homology; Tumor antigen BJ HCC 5; Tumor antigen BJ-HCC-5.
Research Area	Tumour  Cell biology  Signal transduction  Cyclin  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	64kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TPTE: 241-310/551
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TPTE is a 551 amino acid multi-pass membrane protein belonging to the PTEN-related family that is exclusively expressed in the testis and localizes to the plasma membrane in humans. The gene encoding TPTE is present in multiple copies in the human genome, some of which may be pseudogenes. TPTE contains one C2 tensin-type domain and one phosphatase tensin-type domain but, in humans, it does not exhibit phosphatase activity. However, the mouse ortholog (PTEN2) is a functional 3-phosphoinositide phosphatase that localizes to the Golgi apparatus and plays a possible role in signal transduction. In humans, four isoforms, namely TPTEå, TPTE∫, TPTE© and TPTE∂, are produced by alternative splicing of this gene. Function: Could be involved in signal transduction. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Exclusively expressed in testis. Similarity: Contains 1 C2 tensin-type domain. Contains 1 phosphatase tensin-type domain. SWISS: P56180 Gene ID: 7179 Database links: Entrez Gene: 7179 Human Omim: 604336 Human SwissProt: P56180 Human Unigene: 122986 Human

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