Product Name	SIPA1L2
Chinese Name	信号诱导增殖相关蛋白1样蛋白2抗体
Alias	SI1L2_HUMAN; Signal induced proliferation associated 1 like protein 2; Signal-induced proliferation-associated 1-like protein 2; SIPA1 like protein 2; SIPA1-like protein 2; SIPA1L2; SPAL2; KIAA1389.
Research Area	Cell biology  Signal transduction  Cyclin  Cell differentiation  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	190kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SIPA1L2: 251-350/1722
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SIPA1L2 is a 1,722 amino acid protein that contains one PDZ (DHR) domain and one Rap-GAP domain, and exists as two alternatively spliced isoforms. The gene that encodes SPA-L2 consists of approximately 163,594 bases and maps to human chromosome 1q42.2. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Similarity: Contains 1 PDZ (DHR) domain. Contains 1 Rap-GAP domain. SWISS: Q9P2F8 Gene ID: 57568 Database links: Entrez Gene: 57568 Human Entrez Gene: 361442 Rat Omim: 611609 Human SwissProt: Q9P2F8 Human SwissProt: Q80TE4 Mouse SwissProt: Q5JCS6 Rat Unigene: 268774 Human Unigene: 271668 Mouse Unigene: 463243 Mouse Unigene: 44190 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SIPA1L2) Polyclonal Antibody, Unconjugated (SL7927R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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