Product Name	GPSM1
Chinese Name	G protein signal调节蛋白1抗体
Alias	Activator of G-protein signaling 3; AGS3; AGS3 homolog; C10a; G protein signaling modulator 1 (AGS3 like, C. elegans); G-protein-signaling modulator 1; GPSM1; GPSM1_HUMAN.
Research Area	Cell biology  Developmental biology  Neurobiology  Signal transduction  Cyclin  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	75kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GPSM1: 201-300/675
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Subunit: Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1. Subcellular Location: Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in intestinal cells. Post-translational modifications: Phosphorylation regulates interaction with G(i/o) alpha. Similarity: Belongs to the GPSM family. Contains 4 GoLoco domains. Contains 9 TPR repeats. SWISS: Q86YR5 Gene ID: 26086 Database links: Entrez Gene: 26086 Human Entrez Gene: 67839 Mouse Entrez Gene: 246254 Rat Omim: 609491 Human SwissProt: Q86YR5 Human SwissProt: Q6IR34 Mouse SwissProt: Q9R080 Rat Unigene: 239370 Human

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