Product Name	DLL3
Chinese Name	Notch信号通路Delta样配体3抗体
Alias	Delta Drosophila like 3; Delta like 3 Drosophila; Delta like 3 homolog Drosophila; Delta like 3 protein; Delta like protein 3 precursor; Delta3; Drosophila Delta homolog 3; SCDO1; Spondylocostal dysostosis autosomal recessive.DLL3_HUMAN
literatures	Specific References  (1)     |     SL7860R has been referenced in 1 publications. [IF=2.886] Xiao Fu. et al. PD-L1 Predicts Poor Prognosis in Surgically Resected Limited Stage Small-Cell Lung Cancer. Cancer Manag Res. 2020; 12: 10939–10948  IHC ;  Human.   PubMed:33154673
Research Area	Cell biology  Developmental biology  Neurobiology  Signal transduction  Cyclin  Cell differentiation  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	65kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DLL3: 51-150/618 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Delta-like 3 (DLL3) is a transmembrane Delta-like protein that inhibits primary neurogenesis. It may be required to divert neurons along a specific differentiation pathway and plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 is one of five DSL proteins that bind to the Notch receptor and activates Notch signaling. Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Subunit: Can bind and activate Notch-1 or another Notch receptor (Probable). Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis. Post-translational modifications: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. DISEASE: Note=A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities. Similarity: Contains 1 DSL domain. Contains 6 EGF-like domains. SWISS: Q9NYJ7 Gene ID: 10683 Database links: Entrez Gene: 505993 Cow Entrez Gene: 10683 Human Entrez Gene: 100520433 Pig Omim: 602768 Human SwissProt: Q9NYJ7 Human Unigene: 127792 Human
Product Picture	Sample: Fetal brain (Mouse) Lysate at 40 ug Primary: Anti-DLL3 (SL7860R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD

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