Product Name	ALOXE3
Chinese Name	过氧化氢异构酶ALOXE3抗体
Alias	Arachidonate lipoxygenase 3; e LOX 3; E LOX; e-LOX-3; eLOX3; Epidermal lipoxygenase; Epidermis-type lipoxygenase 3; Lipoxygenase 3; LOXE3_HUMAN.
literatures	Specific References  (2)     |     SL7856R has been referenced in 2 publications. [IF=10.753] Jiankang Wang. et al. PM2.5 caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis. SCI TOTAL ENVIRON. 2023 May;872:162089  WB ;  Mouse.   PubMed:36781135 [IF=6.244] Chen Y. et al. Prognostic and Predictive Models for Left- and Right- Colorectal Cancer Patients: A Bioinformatics Analysis Based on Ferroptosis-Related Genes.. Front Oncol. 2022 Feb;12:833834-833834  IHC ;  Human.   PubMed:35265525
Research Area	Cell biology  Signal transduction  Cyclin  Cell differentiation  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ALOXE3: 141-240/711
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. Tissue specificity:Predominantly expressed in skin. Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Tissue Specificity: Predominantly expressed in skin. Similarity: Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain. SWISS: Q9BYJ1 Gene ID: 59344 Database links: Entrez Gene: 59344 Human Entrez Gene: 23801 Mouse Entrez Gene: 287424 Rat Omim: 607206 Human SwissProt: Q9BYJ1 Human SwissProt: Q9WV07 Mouse Unigene: 232770 Human Unigene: 41989 Mouse Unigene: 8716 Rat

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