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Product Name SKA1 Chinese Name 纺锤体和着丝粒相关蛋白1抗体 Alias Ska1; SKA1_HUMAN; Spindle and kinetochore associated complex subunit 1; Spindle and kinetochore associated protein 1; Spindle and kinetochore-associated protein 1; Spindle and KT (kinetochore) associated 1; Spindle and KT associated 1; C18orf24; MGC10200. literatures Specific References (2) | SL7846R has been referenced in 2 publications.[IF=5.173] Zheng Li. et al. SKA1 is overexpressed in laryngocarcinoma and modulates cell growth via P53 signaling pathway. CELL CYCLE. 2022 Nov 17 WB, IHC ; Human.[IF=3.642] Ming-Chuang Sun. et al. ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2. INT J MED SCI. 2022; 19(6): 1072–1081 WB ; Human.Research Area Cell biology immunology Cyclin Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 29kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SKA1: 181-255/255 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.
Subunit:
Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA2; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with microtubules, SKA2 and SKA3.
Subcellular Location:
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Similarity:
Belongs to the SKA1 family.
SWISS:
Q96BD8
Gene ID:
220134
Database links:
Entrez Gene: 220134 Human
Entrez Gene: 66468 Mouse
SwissProt: Q96BD8 Human
SwissProt: Q9CPV1 Mouse
Unigene: 134726 Human
Unigene: 283406 Mouse
Unigene: 106906 Rat
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