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Cytochalasin H
Molecular formula: C30H39NO5, molecular weight: 493.6
Physical properties and indexes:
Appearance: …………………… White freeze-dried powder
Solubility: ………………… Soluble in DMSO, ethanol
Burning residue: ……………… < 0.1%
Purity: …………………… > 95%
Biological activity:
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin H is a potent inhibitor of actin incorporation into filaments. Like cytochalasin D, it also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening. Cytochalasin H suppresses the production of reactive oxygen species by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes, and shows anti-angiogenic activity bothin vitroandin vivo
Use and description: scientific research reagent.
Storage condition: -15~-20°C
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