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Leukemia Inhibitory Factor(LIF),Human,Recombinant Brief introduction:Leukemic suppressor factor (LIF) is a multipotent cytokine belonging to the long quadruple helix bundle cytokine superfamily. The tertiary structure of LIF is similar to interleukin-6 (IL-6), tumor suppressor M, ciliary neurotrophin, myocardial trophin-1 and other cytokines, and its functions in vivo are also redundant to a certain extent. LIF binds to the common receptor of the IL-6 subfamily (gp130) and then forms a ternary complex with its own receptor, the LIF receptor. The basic expression level of LIF in vivo is low, and its expression is induced by lipopolysaccharide, IL-1, IL-17 and other pro-inflammatory factors, and inhibited by IL-4, IL-13 and other anti-inflammatory drugs. The functions of LIF include primordial germ cell proliferation, blastocyst implantation and early pregnancy regulation, and pluripotent stem cell maintenance.Recombinant Human Leukemia Inhibitor (rhLIF) is a 180 amino acid non-glycated polypeptide chain produced by Escherichia coli with a molecular mass of 19.7kDa.Nicknames: Leukemia Inhibitory Factor(LIF),Human,Recombinant; D factor; MLPLIPhysical properties and indexes:Purity: >95%Endotoxin: <0.2EU/μgTiter: >5x 106units/mgExpression host: E. coliSource: HumanPurification Method: purification by chromatographyCharacter: This product is white loose bodyStability: Freeze-dried powder can be stored at -20℃ for 12 months, dissolved liquid can be stored at -20℃ for 3 months, 2 weeks at 4℃, and avoid repeated freeze-thawAmino acid sequence:SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANALFILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKLVELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATADILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKKLGCQLLGKYK QIIAVLAQAF
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