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Product Name ccnb1ip1 Chinese Name 周期蛋白B1Binding protein1抗体 Alias C14orf18; CCNB1IP1; Chromosome 14 open reading frame 18; CIP1_HUMAN; Cyclin B1 interacting protein 1; Cyclin-B1-interacting protein 1; E3 ubiquitin-protein ligase CCNB1IP1; Enhancer of invasion 10; HEI10; Human enhancer of invasion 10. Research Area Cell biology Cyclin Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 32kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ccnb1ip1: 151-250/277 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Tissue specificity: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Function:
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Subunit:
Binds CCNB1 and UBE2L3.
Subcellular Location:
Nucleus. Chromosome. Note=May associate with segregating chromosomes during metaphase and anaphase.
Tissue Specificity:
Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Post-translational modifications:
Ubiquitinated; autoubiquitinated.
Phosphorylated by CDK1 on serine or threonine residues (in vitro).
Similarity:
Contains 1 RING-type zinc finger.
SWISS:
Q9NPC3
Gene ID:
57820
Database links:Entrez Gene: 57820 Human
Omim: 608249 Human
SwissProt: Q9NPC3 Human
Unigene: 107003 Human
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