Product Name	SEPT10
Chinese Name	Cell differentiation蛋白SEPT10抗体
Alias	SEPT 10; SEPT-10; Septin 10; Septin-10; Septin 10; SEP10_HUMAN.
Research Area	Cell biology  Cyclin  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Pig, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SEPT10: 121-220/454
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The SEPT10 gene encodes a member of the septin family of cytoskeletal proteins which have GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternate splicing results in two transcript variants encoding different isoforms. Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Using a GFP-fusion protein, detected in the nucleus (PubMed:12711328). Tissue Specificity: Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines. Similarity: Belongs to the septin family. SWISS: Q9P0V9 Gene ID: 151011 Database links: Entrez Gene: 151011 Human Entrez Gene: 103080 Mouse Omim: 611737 Human SwissProt: Q9P0V9 Human SwissProt: Q8C650 Mouse Unigene: 469615 Human Unigene: 346842 Mouse Unigene: 397041 Mouse SEPTIN(SEPT)家族是Cytoskeleton蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与The nucleus分裂、The cell membrane的运输以及构成Cytoskeleton。
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti- SEPT10 (SL7770R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD

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