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Product Name SEPT1 Chinese Name Cell differentiation蛋白SEP1抗体 Alias DIFF6; Differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase); LARP; Peanut like protein 3; PNUTL3; SEP1; Septin 1; Septin1; Serologically defined breast cancer antigen NY BR 24; SEPT1_HUMAN. Research Area Tumour Neurobiology Signal transduction Cyclin Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 40kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SEPT1: 161-260/367 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail SEPT1 is a member of the septin family of GTPases. Members of this family are required for cytokinesis. SEPT1 is associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.
Function:
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton.
Tissue Specificity:
Expressed at high levels in lymphoid and haematopoietic tissues.
Similarity:
Belongs to the septin family.
SWISS:
Q8WYJ6
Gene ID:
1731
Database links:
Entrez Gene: 1731 Human
Entrez Gene: 54204 Mouse
Omim: 612897 Human
SwissProt: Q8WYJ6 Human
SwissProt: P42209 Mouse
Unigene: 632176 Human
Unigene: 18 Mouse
Unigene: 68675 Rat
SEPTIN(SEPT)家族是Cytoskeleton蛋白的一种,具有GTPase的活性。经研究发現,SEPT参与The nucleus分裂、The cell membrane的运输以及构成Cytoskeleton。
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