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Rabbit Anti-SEPT1 antibody
Rabbit Anti-SEPT1 antibody
DIFF6; Differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase); LARP; Peanut like protein 3; PNUTL3; SEP1; Septin 1; Septin1; Serologically defined breast cancer antigen NY BR 24; SEPT1_HUMAN.
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  • NO.:SL7769R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Horse,)
    Applications:ELISA IHC-P IHC-F IF
    concentration:1mg/ml
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Details

Product Name SEPT1
Chinese Name Cell differentiation蛋白SEP1抗体
Alias DIFF6; Differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase); LARP; Peanut like protein 3; PNUTL3; SEP1; Septin 1; Septin1; Serologically defined breast cancer antigen NY BR 24; SEPT1_HUMAN.  
Research Area Tumour  Neurobiology  Signal transduction  Cyclin  Cell differentiation  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 40kDa
Cellular localization cytoplasmic 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human SEPT1: 161-260/367 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail SEPT1 is a member of the septin family of GTPases. Members of this family are required for cytokinesis. SEPT1 is associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.

Function:
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton.

Tissue Specificity:
Expressed at high levels in lymphoid and haematopoietic tissues.

Similarity:
Belongs to the septin family.

SWISS:
Q8WYJ6

Gene ID:
1731

Database links:

Entrez Gene: 1731 Human

Entrez Gene: 54204 Mouse

Entrez Gene: 293507 Rat

Omim: 612897 Human

SwissProt: Q8WYJ6 Human

SwissProt: P42209 Mouse

SwissProt: Q5EB96 Rat

Unigene: 632176 Human

Unigene: 18 Mouse

Unigene: 68675 Rat



SEPTIN(SEPT)家族是Cytoskeleton蛋白的一种,具有GTPase的活性。经研究发現,SEPT参与The nucleus分裂、The cell membrane的运输以及构成Cytoskeleton。

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