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Product Name HIPK4 Chinese Name 同源相互作用蛋白激酶4抗体 Alias HIPK 4; HIPK4; HIPK4_HUMAN; Homeodomain interacting protein kinase 4; Homeodomain-interacting protein kinase 4. Research Area Cell biology Signal transduction Apoptosis Cyclin Kinases and Phosphatases Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 69kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HIPK4: 251-350/616 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. The homeodomain-interacting protein kinases (HIPK1, HIPK2, HIPK3 and HIPK4) comprise a subfamily of kinase proteins that have a conserved protein kinase domain, as well as a separate domain that interacts with homeoproteins. HIPK4 (Homeodomain-interacting protein kinase 4) is a 616 amino acid protein that localizes to the cytoplasm and exists as two isoforms that are produced by alternative splicing events. Like other members of the HIPK family, HIPK4 functions as a protein kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to act as a corepressor of target transcription factors.
Function:
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors.
Subcellular Location:
Cytoplasm (By similarity).
Post-translational modifications:
Autophosphorylated (By similarity).
Similarity:
Belongs to the protein kinase superfamily. CMGCSer/Thr protein kinase family. HIPK subfamily.
Contains 1 protein kinase domain.
SWISS:
Q8NE63
Gene ID:
147746
Database links:Entrez Gene: 147746 Human
Entrez Gene: 233020 Mouse
Omim: 611712 Human
SwissProt: Q8NE63 Human
SwissProt: Q3V016 Mouse
Unigene: 79363 Human
Unigene: 429716 Mouse
Unigene: 41008 Rat
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