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Product Name AUP1 Chinese Name 原始广泛存在蛋白1抗体 Alias AA589454; AUP 1; AUP1_HUMAN; Ancient ubiquitous protein 1. Research Area Cardiovascular Cell biology Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 53kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human AUP1/Ancient ubiquitous protein 1: 381-476/476 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Ancient ubiquitous protein 1 (AUP1) contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. It has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits.
Function:
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
Subunit:
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.
Tissue Specificity:
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
Similarity:
Belongs to the AUP1 family.
Contains 1 CUE domain.
SWISS:
Q9Y679
Gene ID:
550
Database links:Entrez Gene: 550 Human
Entrez Gene: 11993 Mouse
Omim: 602434 Human
SwissProt: Q9Y679 Human
SwissProt: P70295 Mouse
Unigene: 411480 Human
Unigene: 386752 Mouse
Unigene: 198163 Rat
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