Product Name	SIRT4
Chinese Name	沉默调节相关蛋白4抗体
Alias	NAD dependent deacetylase sirtuin 4; NAD-dependent ADP-ribosyltransferase sirtuin-4; Silent mating type information regulation 2 homolog; Sir 2 like 4; SIR 2 like protein 4; Sir2 like 4; SIR2 like protein 4; SIR2-like protein 4; SIR2L 4; SIR2L4; SIRT 4; Sirt4; SIRT4_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 4; Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); Sirtuin 4; Sirtuin type 4; Sirtuin4.
literatures	Specific References  (4)     |     SL7537R has been referenced in 4 publications. [IF=10.787] Chih-Chang Chao. et al. SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease. REDOX BIOL. 2022 Dec;58:102534  WB ;  Human.   PubMed:36379180 [IF=6.317] Ai-Wen Kang. et al. Puerarin extends the lifespan of Drosophila melanogaster by activating autophagy. FOOD FUNCT. 2023 Feb;:  WB ;  Drosophila melanogaster.   PubMed:36752212 [IF=1.11] Takumida, Masaya, Hiroshi Takumida, and Matti Anniko. "Localization of sirtuins in the mouse inner ear." Acta Oto-Laryngologica 0 (2014): 1-8.  IHC-F ;  Mouse.   PubMed:24460154 [IF=1.1] Takumida, Masaya, et al. "Localization of sirtuins (SIRT1-7) in the aged mouse inner ear." Acta oto-laryngologica (2015): 1-12.  other ;   PubMed:26472659
Research Area	Cardiovascular  Cell biology  Signal transduction  Diabetes  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Fruit Fly, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4: 51-150/314
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity. Function: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity. Subunit: Interacts with GLUD1, IDE and SLC25A5. Subcellular Location: Mitochondrion matrix. Tissue Specificity: Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. Similarity: Belongs to the sirtuin family. Class II subfamily. Contains 1 deacetylase sirtuin-type domain. SWISS: Q9Y6E7 Gene ID: 23409 Database links: Entrez Gene: 519328 Cow Entrez Gene: 23409 Human Entrez Gene: 75387 Mouse Entrez Gene: 100125349 Pig Entrez Gene: 304539 Rat Omim: 604482 Human SwissProt: Q1JQC6 Cow SwissProt: Q9Y6E7 Human SwissProt: Q8R216 Mouse Unigene: 50861 Human Unigene: 332616 Mouse
Product Picture	Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-SIRT4 (SL7537R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 32 kD

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