Product Name	TBX22
Chinese Name	TBX22蛋白抗体
Alias	ABERS; CLPA; CPX; D230020M15Rik; dJ795G23.1; T box 22; T box protein 22; T box transcription factor TBX22; T-box protein 22; T-box transcription factor TBX22; Tbx22; TBX22_HUMAN; TBXX.
Research Area	Developmental biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	58kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TBX22: 1-100/520
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Subcellular Location: Nucleus. Tissue Specificity: Seems to be expressed at a low level. DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:A congenital mouth abnormality characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or one which is attached too near the tip of the tongue. Similarity: Contains 1 T-box DNA-binding domain. SWISS: Q9Y458 Gene ID: 50948 Database links: Entrez Gene: 50945 Human Entrez Gene: 245572 Mouse Entrez Gene: 302369 Rat Omim: 300307 Human SwissProt: Q9Y458 Human SwissProt: Q8K402 Mouse Unigene: 374253 Human Unigene: 137011 Mouse Unigene: 109981 Rat

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