Product Name	GnRH I/GnRH
Chinese Name	促性腺激素释放激素1抗体
Alias	GNRH 1; GnRH associated peptide 1; GNRH1; Gonadotrophin Releasing Hormone 1; GRH; HH12; GON1_HUMAN; LHRH; LNRH; Luliberin I; Luteinizing releasing hormone; Lutenizing Hormome Releasing Hormone; Progonadoliberin 1; Progonadoliberin I; Progonadoliberin1; ProgonadoliberinI; Prolactin Release Inhibiting Factor; Prolctin.
Research Area	Cell biology  Developmental biology  Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	7.8kDa
Cellular localization	cytoplasmic Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GnRH I/GnRH: 37-92/92
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012] Function: Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe. Subcellular Location: Secreted SWISS: P01148 Gene ID: 2796 Database links: Entrez Gene: 2796 Human Entrez Gene: 14714 Mouse Entrez Gene: 397516 Pig Entrez Gene: 25194 Rat Omim: 152760 Human SwissProt: P01148 Human SwissProt: P13562 Mouse SwissProt: P49921 Pig SwissProt: P07490 Rat SwissProt: Q28588 Sheep

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