Product Name	SEC61 beta
Chinese Name	TransporterSEC61β亚基抗体
Alias	SEC61B Protein translocation complex beta; Protein transport protein SEC61 beta subunit; Protein transport protein Sec61 subunit beta; SEC 61B; SC61B_HUMAN; SEC61; SEC61 B; Sec61 beta subunit; Sec61 complex beta subunit.
Research Area	Cell biology  immunology  Signal transduction  Transmembrane protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	9.8kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SEC61 beta: 2-50/96
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008] Function: Necessary for protein translocation in the endoplasmic reticulum. Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62. Similarity: Belongs to the SEC61-beta family. SWISS: P60468 Gene ID: 10952 Database links: Entrez Gene: 10952 Human Entrez Gene: 66212 Mouse Entrez Gene: 298068 Rat Omim: 609214 Human SwissProt: P60467 Dog SwissProt: P60468 Human SwissProt: Q9CQS8 Mouse Unigene: 191887 Human Unigene: 20188 Mouse Unigene: 103030 Rat
Product Picture	Tissue/cell: Human 293FT cell;4% Paraformaldehyde-fixed; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-SEC61 bata Polyclonal Antibody, Unconjugated(SL7404R) 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, Cy5 conjugated(SL0295G-Cy5)used at 1:200 dilution for 40 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei

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